Cefalosporină - Antibiotic - Acremonium

Structura chimică generală a cefalosporinelor
Cefalosporinele alcătuiesc o clasă de antibiotice beta-lactamice care au fost izolate iniţial din specii de fungi din genul Acremonium, denumit în trecut "Cephalosporium". Împreună cu cefamicinele, alcătuiesc clasa cefemelor. Au fost descoperite în 1945 şi au fost comercializate pentru prima dată în anul 1964.
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KEGGKEGG (Kyoto Encyclopedia of Genes and Genomes) este o colecţie de baze de date despre genomuri, căi biologice, boli, medicamente şi substanţe chimice.   C00875
Cod ATCClasificarea anatomică, terapeutică şi chimică reprezintă un sistem de clasificare a medicamentelor în funcţie de codul ATC.  J01DB


Date biologice şi biochimice
 

  Ciuperca Cephalosporium acremonium care a initiat prima sursă de cefalosporine a fost izolată de Brotzu în mare, lângă apele de canalizare de pe coasta Sardiniei. Ciuperca sardă a fost verificată să conțină 3 antibiotice definite: cefalosporina P (activă împotriva gram-pozitivă), cefalosporina N (activă împotriva gram-pozitivă și gram-negativă) și cefalosporina C (mai puțin puternică decât cea anterioară, dar cu aceeași activitate antimicrobiană).

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  Antibioticele beta-lactam (ce cuprind: peniciline, carbapeneme, monobactami, cefalosporine) acționează prin blocarea etapei finale în sinteza peretelui celular bacterian, inhibând sinteza de peptidoglican, antrenând astfel liza și moartea celulară. (Bakker, 1997Bakker E1, Bühlmann P, Pretsch E. (1997). "Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 1. General Characteristics". Chem. Rev. 97 (8): 3083–3132. doi:10.1021/cr940394a. PMID 11851486)
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Imagini şi Videoclipuri

Mecanismul de actiune al cefalosporinelor   01  
Mecanismul de actiune
al cefalosporinelor Shahbaz, Kiran. (2017). Cephalosporins: pharmacology and chemistry. Pharmaceutical and Biological Evaluations. 4. 234. 10.26510/2394-0859.pbe.2017.36.
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Transductia semnalului in receptorii cuplati cu proteina G.jpg   07  
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Compararea a patru structuri GPCR   08  
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Bibliografie
 
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